TNF superfamily members play distinct roles in shaping the thymic stromal microenvironment.

Rudolf Bichele,Kai Kisand,Pärt Peterson,Martti Laan

Molecular Immunology（2016）

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摘要

•RANKL specifically induces Aire and autoantigen expression in the thymic stroma.•TNFα and LTβ induce the expression of key thymic chemokines.•RANKL and LTβ work synergistically to establish the thymic microenvironment.•Specific gene expression patterns may be attributable to differential NF-κB binding.

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关键词

Aire,αLTβR,FTOC,HVEM,IPA,KO,LIGHT,LTβ(LTβR),NF-κB,qRT-PCR,RANK (RANKL),TCR,TEC (mTEC/cTEC),TFBS,TNFα,TNF(R)SF,TRA

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