Steric trapping reveals a cooperativity network in the intramembrane protease GlpG

Ruiqiong Guo,Kristen Gaffney,Zhongyu Yang,Miyeon Kim,Suttipun Sungsuwan,Xuefei Huang,Wayne L Hubbell,Heedeok Hong

NATURE CHEMICAL BIOLOGY（2016）

引用 45|浏览5

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摘要

steric trapping method for monitoring membrane protein folding under native conditions shows an expanded unfolded state of the GlpG intramembrane protease and identifies a network of cooperative interactions at side chain resolution for maintaining its stability.

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关键词

Biophysical chemistry,Biochemistry,Membranes,Protein folding

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