Feasibility of implanted upper airway nerve stimulation therapy to treat obstructive sleep apnea

We studied a second generation Upper Airway Stimulation system (Inspire Medical Systems, Inc) in OSA with an attempt to identify baseline predictors of therapy success. Moderate-to-severe OSA patients who failed, or were intolerant of, continuous positive airway pressure were included. The study was conducted in 2 phases. In Phase 1, patients were enrolled with broad selection criteria. In Phase 2, patients were enrolled using selection criteria derived from the experience in Phase 1. 20 of 22 patients enrolled in Phase 1 (2 exited the study) were examined for factors predictive of a response (AHI We conclude that site of obstruction, baseline AHI, and BMI may be important therapy success predictors.