Preclinical pharmacokinetic evaluation of praziquantel loaded in poly (methyl methacrylate) nanoparticle using a HPLC–MS/MS

Mayara Malhado,Douglas Pereira Pinto, Aline C A Silva, Gabriel P E Silveira,Heliana M Pereira, Jorge G F Santos,Carla V V Guilarducciferraz,Alessandra Lifsitch Vicosa,Marcio Nele,Lais B Fonseca,Jose Carlos C S Pinto,Sabrina Calilelias

Journal of Pharmaceutical and Biomedical Analysis（2016）

引用 16|浏览11

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摘要

•Pharmacokinetic profile of poly (methyl methacrylate) nanoparticle loaded with PZQ.•Analytical method for analysis of PZQ in rat plasma was developed using HPLC–MS/MS.•Validation method and pharmacokinetic study of PZQ nanoparticle.

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关键词

Praziquantel,Poly (methyl methacrylate) nanoparticle,Pharmacokinetic,HPLC–MS/MS

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