Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals

Sally Woodman,A Gibson,Ana Rubio Garcia,Guillermo Sanchez Contreras,John W Rossen,Dirk Werling,Victoria Offord

Veterinary Immunology and Immunopathology（2016）

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摘要

•We characterise novel pinniped TLR1 and TLR6 nucleotide sequences.•We generate comparative protein models of pinniped TLR1 and TLR6.•We discuss the evolutionary history of pinniped TLR1 and TLR6.•We identify lineage-specific residues from mammalian sequence alignments.•We describe pinniped-specific TLR1 residue T317 known to bind Pam3CSK4 in humans.

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关键词

Toll-like receptor,Pinniped,Evolution,Zoonosis,Conservation

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