sGCα 1 β 1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Emmanuel S Buys,Anje Cauwels,Michael J Raher,Jonathan J Passeri,Ion Hobai,Sharon M Cawley,Kristen M Rauwerdink,Helene Thibault,Patrick Y Sips,Robrecht Thoonen,Marielle Scherrer-Crosbie,Fumito Ichinose,Peter Brouckaert,Kenneth D Bloch

American Journal of Physiology-heart and Circulatory Physiology（2009）

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摘要

Altered cGMP signaling has been implicated in myocardial depression, morbidity, and mortality associated with sepsis. Previous studies, using inhibitors of soluble guanylate cyclase (sGC), suggeste...

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关键词

Murine Model,Left Ventricular Function,Cardiac Myocytes,Cardiac Dysfunction,Guanylate Cyclase

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