[F-18]Fluorination Optimisation And The Fully Automated Production Of [F-18]Mel050 Using A Microfluidic System
AUSTRALIAN JOURNAL OF CHEMISTRY（2015）
摘要
The [F-18]radiolabelling of the melanin-targeting positron-emission tomography radiotracer [F-18]MEL050 was rapidly optimised using a commercial continuous-flow microfluidic system. The optimal [F-18]fluorination incorporation conditions were then translated to production-scale experiments (35-150 GBq) suitable for preclinical imaging, complete with automated HPLC-solid phase extraction purification and formulation. [F-18]MEL050 was obtained in 43 +/- 10% radiochemical yield in similar to 50min.
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关键词
surface chemistry,organic chemistry,mass spectrometry,amino acids,educational,photochemistry,physical chemistry,enzymes,green chemistry,catalysis,colloids,inorganic chemistry,macromolecules,crystal structures,peptide,biosensors,sensors,ab initio calculations,kinetics,analytical chemistry,medicinal chemistry,electrochemistry,self assembly,biological chemistry,combinatorial chemistry,supramolecular chemistry,density functional theory,combinatorial,computational chemistry,polymer chemistry,nanotechnology,proteins,pharmaceutical chemistry,spectroscopy,reaction mechanisms,interfaces,ionic liquids,structure,biocatalysis,quantum chemistry,crystallography
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