YAP and TAZ: a nexus for Hippo signaling and beyond

•YAP and TAZ are major downstream effectors of the Hippo pathway.•YAP and TAZ function as signaling manifolds in the nucleus and the cytoplasm.•The Hippo pathway interacts on multiple levels with many other signaling pathways and organelles.•The Hippo network is a potent regulator of tissue regeneration and stem cell biology.