Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia

CHEMISTRY OF NATURAL COMPOUNDS(2015)

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摘要
new amide, beilschamide ( 1 ), has been isolated from the stem of Beilschmiedia erythrophloia , together with seven known compounds, N-trans -feruloyltyramine ( 2 ), N-trans -feruloyloctopamine ( 3 ), vanillin ( 4 ), α -tocopheryl quinone ( 5 ), β -sitostenone ( 6 ), β -sitosterol ( 7 ), and 6 α -hydroxystigmast-4-en-3-one ( 8 ). The structure of the new compound 1 was determined through spectroscopic and MS analyses. N-trans -Feruloyloctopamine ( 3 ) and beilschamide ( 1 ) exhibited cytotoxic effects with IC 50 values of 10.3 and 21.2 μg/mL, respectively, against CCRF-CEM cell line.
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关键词
Beilschmiedia erythrophloia,amide,beilschamide
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