International Atomic Energy Agency Randomized Phase Iii Study Of Radiation Therapy In Elderly And/Or Frail Patients With Newly Diagnosed Glioblastoma Multiforme
JOURNAL OF CLINICAL ONCOLOGY(2015)
摘要
PurposeThe optimal radiotherapy regimen for elderly and/or frail patients with newly diagnosed glioblastoma remains to be established. This study compared two radiotherapy regimens on the outcome of these patients.Patients and MethodsBetween 2010 and 2013, 98 patients (frail = age >= 50 years and Karnofsky performance status [KPS] of 50% to 70%; elderly and frail = age >= 65 years and KPS of 50% to 70%; elderly = age >= 65 years and KPS of 80% to 100%) were prospectively randomly assigned to two arms in a 1:1 ratio, stratified by age (< and >= 65 years old), KPS, and extent of surgical resection. Arm 1 received short-course radiotherapy (25 Gy in five daily fractions over 1 week), and arm 2 received commonly used radiotherapy (40 Gy in 15 daily fractions over 3 weeks).ResultsThe short-course radiotherapy was noninferior to commonly used radiotherapy. The median overall survival time was 7.9 months (95% CI, 6.3 to 9.6 months) in arm 1 and 6.4 months (95% CI, 5.1 to 7.6 months) in arm 2 (P = .988). Median progression-free survival time was 4.2 months (95% CI, 2.5 to 5.9) in arm 1 and 4.2 months (95% CI, 2.6 to 5.7) in arm B (P = .716). With a median follow-up time of 6.3 months, the quality of life between both arms at 4 weeks after treatment and 8 weeks after treatment was not different.ConclusionThere were no differences in overall survival time, progression-free survival time, and quality of life between patients receiving the two radiotherapy regimens. In view of the reduced treatment time, the short 1-week radiotherapy regimen may be recommended as a treatment option for elderly and/or frail patients with newly diagnosed glioblastoma. (C) 2015 by American Society of Clinical Oncology
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