Is there a relationship between systemic inflammatory markers and abnormal uterine bleeding in unclassifiable cases according to the PALM-COEIN system?

Objective: The aim of this study is to assess the possibility of subclinical inflammation and the difference of SIR markers in cases with abnormal uterine bleeding (AUB). Materials and Methods: A total of 529 women were enrolled in the study. Patients were classified according to diagnostic categories of PALM-COEIN. The comparisons between the groups were analyzed by one way variant analysis and Kruskal-Wallis analysis. Relations between numerical variables were assessed by Spearman Correlation analysis. Results: No significant difference was found between the groups for SIR markers. When SIR markers were compared between the groups Neutrophil / lymphocyte ratio (NLR) was negatively correlated with lymphocyte/platelet ratio (LPR) in all the groups. Although a strong negative correlation was detected between NLR and lymphocyte/monocyte ratio (LMR) in Groups 2, 3, and 4, no significant relation was detected in Group 1. Conclusions: In this study, no significant difference of SIR markers was observed between AUB cases with functional or structural abnormalities and unclassifiable AUB cases according to PALM-COEIN classification.