Improvement in the Ultrastructures of Nervous Tissues Damaged in Cerebral Ischemic Rate by Picroside II

The aim of present study was to verify the neuroprotective effect of picroside II on cerebral ischemic injury in rats from the perspective of neuropathology. Healthy adult male Wistar rats were used to establish the forebrain ischemic model. Transmission Electron Microscopy (TEM) was used to observe the ultrastructure of neurons, astrocytes, myelin and the Blood-Brain Barrier (BBB). There was morphological damage in neuron, astrocyte, myelin and BBB after cerebral ischemia. After treatment by picroside II, the degree of damage in neuron, astrocytes, myelin and BBB was reduced. These results suggest that picroside II could significantly improve the morphosis of nerve tissue after cerebral ischemia and play a neuroprotective effect on cerebral ischemic injury in rats.