Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides

Starting from available ribose-building blocks, the 4'-C-methyl-, 4'-C-ethyl- and the new 4'-C-propyl-substituted deoxyuridines were synthesized. Afterwards we converted 4'-C-alkylated-2'-deoxyuridines into the corresponding 4'-C-alkylated-5-iodo-2'-deoxyuridines 3a-c and those in turn into the 4'-C-alkylated-5-iodo-2'-deoxycytidines 4a-c.