Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease

Shaowei Wang,Shigao Yang,Wen Liu,Yangxin Zhang,Pengxin Xu,Teng Wang,Tiejun Ling,Ruitian Liu

Behavioural Brain Research（2016）

引用 51|浏览8

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摘要

•Alpha-tocopherol quinine ameliorates spatial memory deficits in AD transgenic mice.•Alpha-tocopherol quinine decreases Aβ oligomer levels in the brain of AD transgenic mice.•Alpha-tocopherol quinine inhibits microglia activation by inhibiting NF-κB signaling pathway.•Alpha-tocopherol quinine reduces cytokine production and oxidative stress in AD mice.•Alpha-tocopherol quinine has potential therapeutic value for AD treatment.

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关键词

AD,Aβ,α-TQ,MWM,ROS,ThS,Iba-1,MDA,SOD,IL-1β,IL-6

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