Establishment of a GMP-compliant mesenchymal stromal cell bank from pooled bone marrow mononuclear cells of eight “third-party” healthy donors: clinical evidence of safety and efficacy

Zyrafete Kuci,Halvard Bonig,Hermann Kreyenberg,Milica Bunos,Anna Jauch,Johannes W G Janssen,Marijana Skific, Kristina Michel, Ben Eising,Giovanna Lucchini,Andrea Jarisch,Jan Soerensen,Erhard Seifried,Thomas Klingebiel,Peter Bader,Selim Kuci

Cytotherapy（2015）

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摘要

Mesenchymal stromal cells (MSCs) represent a heterogeneous cell population concerning their proliferative, differentiation and allosuppressive potential, which is donor-dependent and may lead to inconsistent clinical data. To circumvent the inter-donor variability, we established a GMP-compliant, serum-free MSC-bank from pooled bone marrow mononuclear cells (BM-MNCs) of 8 healthy donors.

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关键词

stromal cell bank,bone marrow mononuclear cells,bone marrow,healthy donors,gmp-compliant,third-party

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