Nickel-Catalyzed Reductive Alkylation of Halogenated Pyridines with Secondary Alkyl Bromides

SYNTHETIC COMMUNICATIONS(2014)

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摘要
This article highlights Ni-catalyzed cross-electrophile coupling of halogenated pyridines with secondary alkyl bromides using zinc as the terminal reductant. With this protocol, we have successfully achieved different alkyl-substituted pyridines in moderate to excellent yields.
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关键词
Alkylation,cross-coupling,Ni-catalyzed,pyridines,zinc
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