Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi’s sarcoma-associated herpesvirus infection

Christine M. Burrer,Glenna W. Foight,Amy E. Keating,Gary C. Chan

Virus Research（2016）

引用 7|浏览9

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摘要

•Identify 2 novel peptide inhibitors that bind to the viral Bcl-2 homologue KsBcl-2.•Peptides stimulate cytochrome c release from mitochondria of KSHV-infected B cells.•Show KsBcl-2 as a viable target to kill latently KSHV-infected B cells.

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关键词

Kaposi's,sarcoma-associated herpesvirus,B-cell lymphoma (Bcl)-2,Latency,B cells,Peptide inhibitors,Mitochondria

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