LCZ696: a dual-acting sodium supramolecular complex

Lili Feng,Piotr H Karpinski,Paul Allen Sutton,Yugang Liu,David F Hook,Bin Hu,Thomas J Blacklock,Philip E Fanwick,Mahavir Prashad,Sven Erik Godtfredsen, Christoph Ziltener

Tetrahedron Letters（2012）

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摘要

LCZ696 displays several surprising features, such as an intrinsic stabilization of the supramolecular complex by monovalent multi-coordinated sodium cations and water molecules. In addition, to the best of our knowledge, the compound is the first example of a dual-acting pharmaceutical built as a supramolecular complex delivering two pharmacologic effects—angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition.

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关键词

LCZ696,Hypertension,X-ray crystallography,ARNI,Supramolecular complex

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