Chemical synthesis of human adiponectin(19–107) bearing post-translational glycosylation

Masayoshi Mochizuki,Misako Taichi,Hajime Hibino,Ayako Takuwa,Takuya Yoshida,Tadayasu Ohkubo,Yuji Nishiuchi

Tetrahedron Letters（2014）

引用 6|浏览9

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摘要

The chemical synthesis of human adiponectin(19–107), consisting of the variable region and the collagenous domain with glycosylated 5-hydroxylysine residues, was achieved for the first time by employing native chemical ligation and thioester methods.

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关键词

Adiponectin,Glucosylgalactosyl hydroxylysine,Native chemical ligation,Peptide thioester,Post-translational modification

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