Ugi four-center three-component reaction for the parallel solid-phase synthesis of N-substituted thiomopholinones

Tetrahedron Letters（2012）

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摘要

Starting with resin-bound bifunctional 2-(2-aminoethylthio)acetic, an efficient synthesis of a variety of N-cycloakyl thiomopholinones is described utilizing the Ugi four-center three-component reaction (U-4C-3CR).

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关键词

Solid phase synthesis,UGI reaction,MCR,Thiomorpholinones,Heterocycles,Combinatorial chemistry

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