The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

Adeline Fluteau,Paul G Ince,Thais Minett,Fiona E Matthews,Carol Brayne,Claire J Garwood,Laura E Ratcliffe,Sarah V Morgan,Paul R Heath,Pamela J Shaw,Stephen B Wharton,J E Simpson

Neuroscience Letters（2015）

引用 52|浏览21

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摘要

•Nuclear FOXO3a significantly correlates with glutamine synthetase expression.•FOXO3a nuclear localisation correlates with a DNA damage response.•Glutamine synthetase expression correlates with increasing Alzheimer pathology.

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关键词

FOXO3a,Glutamine synthetase,DNA damage response,Astrocyte,neurone,Alzheimer’s,Pathology,Ageing brain

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