Spinal 5-HT1A, not the 5-HT1B or 5-HT3 receptors, mediates descending serotonergic inhibition for late-phase mechanical allodynia of carrageenan-induced peripheral inflammation

Joung Min Kim,Seong Wook Jeong,Jihoon Yang,Seong Heon Lee, Woon Mo Kim,Hong Beom Bae,Myung Ha Yoon,Jeong Il Choi

Neuroscience Letters（2015）

引用 10|浏览6

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摘要

•Spinal 5-HT has an anti-allodynic effect in late-phase carrageenan inflammation.•5-HT1A receptor is involved in anti-nociceptive processing in spinal cord.•Spinal 5-HT1B or 5-HT3 receptor plays a limited role in nociceptive processing.

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关键词

Serotonergic projection,5-Hydroxytryptamine 1A receptor,Carrageenan,Allodynia,Spinal cord

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