Frontline therapy in Chronic Lymphocytic Leukemia
ACTA HAEMATOLOGICA(2024)
摘要
The treatment landscape of chronic lymphocytic leukemia (CLL) has tremendously evolved in the last decades thanks to the introduction of more effective therapies. Front-line therapy for patients with CLL includes chemoimmunotherapy (CIT) and pathway inhibitors (PI) (i.e., Bruton tyrosine kinase inhibitors and BCL2 inhibitors); the latter have proved to be more effective than CIT mainly in patients with high-risk features (eg, TP53 aberrations, unmutated IGHV) with acceptable toxicity. Combinations of PIs are playing a protagonist role as front-line therapy for CLL. In this article, the management of treatment- naive patients with CLL is discussed.
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关键词
chronic lymphocytic leukemia,frontline therapy,cll
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