TrpE feedback mutants reveal roadblocks and conduits toward increasing secondary metabolism in Aspergillus fumigatus

Pin-Mei Wang,Tsokyi Choera,Philipp Wiemann,Tippapha Pisithkul,Daniel Amador-Noguez,Nancy P. Keller

Fungal Genetics and Biology（2016）

引用 20|浏览6

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摘要

•Inactivation of the tryptophan feedback domain in TrpE increases anthranilate levels.•Elevated intracellular anthranilate and tryptophan levels are positively correlated with fumiquinazoline production.•Re-routing metabolic flux of amino acids has the potential to boost NRPS-derived secondary metabolite production.

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关键词

Aspergillus fumigatus,Tryptophan metabolism,Secondary metabolism,Metabolic engineering,Metabolic flux,Fumiquinazoline

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