Enhanced neutralising antibody response to bovine viral diarrhoea virus (BVDV) induced by DNA vaccination in calves

Laila Elattar,Carole Thomas,Jeremy Luke,James A Williams,Joe Brownlie

Vaccine（2015）

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摘要

•Co-expression of a RIG-I agonist with BVDV viral antigen could enhance DNA vaccine potency in cattle.•Integration of RIG-I agonist greatly enhances BVDV neutralising antibody response.•BVDVE2 protein augments antibody response to NS3 in BVDV DNA vaccine.

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关键词

Plasmid DNA vaccine,BVDV marker vaccine,RIG-I agonist

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