P1-375: Efficacy and usability of a brain-computer interface system in improving cognition in the elderly

landmarks. Results: The first results of this study, presented herein, examined the primary outcomemeasure, the Clinician’s Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) global scores (New York University version) (Reisberg,Int. Psychogeriatr., 2007). This assessment comprehensively evaluates change in terms of cognition, function and behavior. The results indicated significant improvement in CIBIC-Plus scores in the subjects in the management program versus the subjects receiving financial compensation (p < 0.01 at weeks 4 and 12 and p < 0.001 at week 28), with enhanced benefits throughout the 28 week study period (see Figure). Conclusions: These initial results strongly demonstrate the very large added benefit of our CI-PCM program in the treatment of persons with moderate to severe AD. At all time points, memantine plus management subjects showed global improvements, and memantine with financial compensation subjects showed continuing global decrements.