Contribution of executive functioning and memory to rule induction in healthy older people and patients with MCI or early dementia

assess the diagnostic accuracy of the Korean version ACE (K-ACE) in a Korean Population. Methods: A total of 168 subjects (70 Alzheimer dementia, 37 Mild cognitive impairment, 61 control) who visited the neurology outpatient clinic of Seoul Medical Center were included. ACE was translated and modified to K-ACE. Sensitivity, specificity, area under curve, reliability, and Verbal-Language/Orientation-Memory (VLOM) ratio were evaluated. The receiver operating characteristic (ROC) curve was used to determine optimal cut-off score in screening dementia. Results:The ROC curves showed the superiority of the K-ACE over Korean Mini-mental Status Examination (K-MMSE) in diagnosis of Alzheimer dementia and Mild cognitive impairment. The optimal cut-off of the K-ACE for the identification of AD was 68/69, which had a sensitivity of 90% and a specificity of 87%. Conclusions: The K-ACE is a short, reliable, and valid neuropsychological test battery to screen dementia in the Korean elderly.