Comparison of manual and automated multi-atlas hippocampal volume measurements in the University of California-Davis Alzheimer's Disease Center patient cohort

at follow-up (r 1⁄4 0.519, p 1⁄4 0.027; Figure 1A) adjusted for baseline precuneus thickness. [11 C]PBR28 signal was also related to RBM analytes including BDNF (r 1⁄4 -0.496, p 1⁄4 0.01; Figure 1B), clusterin (r 1⁄4 -0.417, p 1⁄4 0.03; Figure 1C), and Regulated on Activation Normal T Cell Expressed and Secreted (RANTES) (r 1⁄4 -0.473, p 1⁄4 0.01; Figure 1D) analyte levels. These findings were independent of diagnosis and APOE genotype.Conclusions: Higher [11 C]PBR28 uptake at baseline is associated with subsequently less atrophy, which may suggest that microglial activation may protect against cortical atrophy. [11 C]PBR28 uptake was also associated with altered levels of blood analytes that have been previously implicated in AD pathophysiology. These results are consistent with growing evidence that immune activation may play either a protective or detrimental role in AD, with respect to other neurotrophic and immunological proteins. These context-dependent mechanisms of AD pathology warrant further investigation. [1] Yoder et al. (submitted to J Nucl Med).