BASELINE WHITE MATTER HYPERINTENSITIES AND GRAY MATTER VOLUME INDEPENDENTLY PREDICT COGNITIVE TRAJECTORIES IN ADNI II

Intercept -1.47757 0.769952 0.0555 -1.165109 1.019181 0.2535 49.534624 8.285752 <.0001* Years 0.0305425 0.020896 0.1458 0.0166736 0.027829 0.5495 -0.012889 0.217946 0.9529 Manufacturer[GE] -0.018277 0.06056 0.7630 -0.064457 0.080656 0.4246 0.3426479 0.636646 0.5908 Manufacturer[Philips Healthcare] -0.015972 0.160263 0.9207 -0.04988 0.213798 0.8156 -0.823831 1.676513 0.6236 Dx1[Demented] -0.723688 0.056804 <.0001* -0.869029 0.075278 <.0001* 11.79048 0.611579 <.0001* Dx1[EMCI] 0.2745424 0.035684 <.0001* 0.2624223 0.047254 <.0001* -4.935769 0.384324 <.0001* Dx1[LMCI] -0.197599 0.041695 <.0001* -0.020517 0.055232 0.7104 1.3894833 0.449118 0.0021* Baseline Age -0.015499 0.003571 <.0001* -0.034189 0.004726 <.0001* 0.1167973 0.038448 0.0025* Education 0.0427681 0.008577 <.0001* 0.0663297 0.01135 <.0001* -0.327638 0.092316 0.0004* Gender (male1⁄40) 0.221747 0.045799 <.0001* -0.007108 0.060616 0.9067 -0.940136 0.493217 0.0572 Log Normalized Baseline WMH volume -0.0163 0.021406 0.4467 -0.042841 0.028333 0.1311 0.5713164 0.230408 0.0135* Normalized Baseline Gray matter volume 0.0395477 0.015151 0.0093* 0.059274 0.020052 0.0033* -0.734564 0.163054 <.0001* WMH*Time -0.042524 0.017533 0.0163* -0.004833 0.023336 0.8360 0.5450092 0.182927 0.0033* Gray matter * Time 0.0166567 0.013642 0.2238 0.0367778 0.018202 0.0441* -0.156062 0.142181 0.2738