P4-347: Which MCI subtypes convert to Alzheimer's disease in spite of negative CSF findings?

Background: Plasmapheresis has been used in clinical setting to remove proteins in autoimmune diseases, but is also used to collect plasma from healthy individuals who donate plasma to be used for the manufacture of plasma derived therapeutic proteins. However, the impact of plasmapheresis on plasmatic Ab levels after repeated donations has not been studied. The purpose of this study is to evaluate plasmatic Ab levels of individuals undergoing plasmapheresis.Results:Nomajor age effects were seen in any of the studied proteins. The Ab 1-42 detectable by xMAP technology appeared to be slightly lower in older donors (Table 1). The results obtained according to donation frequency are presented in table 2. The albumin and IgG content slightly decreased with repeated donations, with no alteration on the donors’ health status. The results of A b content, detectable by xMAP technology, showed no differences or marginal differences (data widely overlapped) when comparing both groups. Conclusions: A slight decrease of albumin and IgG content in repeated donors, as previously known, is confirmed. No major effects on Ab content in correlation to donation frequency could be observed.