Impact of pulsed xenon ultraviolet light on hospital-acquired infection rates in a community hospital

•We examine 2 deployments of pulsed xenon ultraviolet disinfection: all discharges (intensive care unit) and Clostridium difficile isolation only (nonintensive care unit).•Use of pulsed xenon ultraviolet disinfection was associated with reductions in hospital-acquired infection rates.•Over 400 rooms per month were disinfected with pulsed xenon ultraviolet disinfection.•Pulsed xenon ultraviolet disinfection was run in three 5-minute positions in each room.