Abstract PD09-02: Prognostic Effect of Obesity on Breast Cancer

Background: Body mass index (BMI), prior estrogen use, and family history have been described as risk factors for invasive breast cancer. Our purpose was to investigate the influence of obesity on established prognostic pathologic and molecular characteristics of breast cancer. Material and methods: Five-hundred and twelve female consecutive breast cancer patients of mean age 53±11 years were included in this study. Data were recorded in a prospective electronic databank upon first presentation. Risk factors (BMI, family history, prior estrogen use, menopausal status, parity, metabolic syndrome, smoking, alcohol, hypertension, hyperlipidaemia and diabetes) as well as histologic characteristics (TNM, nodal status, grade, LVI) and tumor phenotype (ER, PR, Cerb-B2) were obtained. Patients with a BMI Discussion: Different risk factors appear to influence lean and obese breast cancer patients. Patients with BMI 27) have more frequently positive family history and more aggressive histology (node +, grade 3, LVI+). LVI in obese patients appears to be independently associated with node + disease. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD09-02.