Correlates Of Circulating 25-Hydroxyvitamin D Among Cancer Free Adults In The Cohort Consortium Vitamin D Pooling Project

Objective: Vitamin D deficiency and insufficiency are common globally. Because low circulating 25-hydroxyvitamin D [25(OH)D] concentrations measured during adulthood have been associated with several disease outcomes, it is important to understand correlates of circulating 25(OH)D, especially in certain at-risk populations. Methods: Circulating 25(OH)D was assayed in 4,723 adult men and women with no diagnosed cancer from ten cohorts in the United States, Finland and China participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Data on potential correlates were obtained and harmonized by a central data coordinating center. Serum/plasma samples were assayed for 25(OH)D at Heartland Assays, Inc. using the DiaSorin LIAISON 25(OH)D TOTAL assay, a direct, competitive chemiluminescence immunoassay. We used stepwise linear regression and polytomous logistic regression to identify demographic and lifestyle correlates of circulating 25(OH)D. Results: Vitamin D deficiency (defined as 25 kg/m2, and low physical activity were associated with greater risk of vitamin D deficiency ( Conclusions: Vitamin D deficiency and insufficiency were common in this population. Multiple modifiable and non-modifiable factors were correlated with circulating 25(OH)D. These findings help identify individuals at risk for low vitamin D status, which may be useful for both clinical and research purposes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2776.