Abstract 3962: Wnt signaling modulates the Hedgehog pathway by stabilizing GLI1 mRNA

Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Wnt and Hedgehog signaling pathways play central roles in embryogenesis, stem cell maintenance, and tumorigenesis. These two pathways being fundamental in the coordination of developmental transitions, have been postulated to interact, or cross-regulate at multiple levels yet the mechanisms of these interactions are not well-understood. Here, we show that Wnt signaling pathway stimulates the transcriptional output of Hedgehog signaling. We demonstrate that Wnt/β-catenin signaling induces the expression of an RNA-binding protein, CRD-BP, which, in turn, binds and stabilizes GLI1 mRNA, causing an elevation of GLI1 expression and transcriptional activity. The newly described mode of regulation of GLI1 appears to be important to several functions of Wnt, including survival and proliferation of colorectal cancer cells. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3962.