c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.

Jack Leslie,Jill E Hunter,Amy Collins, Amelia Rushton,Lauren G Russell,Erik Ramon-Gil,Maja Laszczewska,Misti McCain,Marco Y W Zaki,Amber Knox, Yixin Seow,Laura Sabater,Daniel Geh,Neil D Perkins,Helen L Reeves,Dina Tiniakos,Derek A Mann,Fiona Oakley

Hepatology (Baltimore, Md.)（2022）

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摘要

Hepatocyte c-Rel signaling limits genotoxic injury and subsequent HCC burden. Inhibiting c-Rel as an adjuvant therapy increased the effectiveness of DNA damaging agents and reduced HCC growth.

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