Gata2: Potential Role As A Prostate Cancer Metastasis-Driving Gene

Metastasis is thought to result from changes in the expression of specific metastasis-driving genes leading to a cascade of activated downstream genes that set the metastatic process in motion. The present study was aimed at identifying such metastasis-driving genes in prostate cancer for potential therapy and identification of primary prostate cancers that are likely to metastasize. To this end, a differential gene expression profile was established of metastatic LTL-313H and non-metastatic LTL-313B prostate cancer tissue xenografts, derived from one patient9s specimen using sub-renal capsule grafting technology. The profile was then subjected to integrative analysis using the Ingenuity Upstream Regulator Analysis tool. Six candidate master regulatory genes were identified, including GATA2, a gene encoding a pioneer factor in prostate cancer. Elevated GATA2 expression in clinical metastatic prostate cancer …