Metabotropic Glutamate Receptors Are Involved In The Detection Of IMP And L-Amino Acids By Mouse Taste Sensory Cells

•Contrary to theory, taste cells of T1r3 KO mice respond to l-amino acids and IMP.•Selective mGluR1 and mGluR4 agonists activate taste cells of mice.•mGluR1 and mGluR4 antagonists block l-amino acids and IMP responses of T1r3 KO mice.•Brain and taste variants of mGluR1 and mGluR4 detect l-amino acids and IMP tastes.