Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat

•7NI and WIN dose-dependently protect from induced epileptiform discharges in MDA.•In pilocarpine model 7NI and WIN reduce behavioral seizures dose-relatedly.•Pretreatment with 7NI enhances anticonvulsant action of WIN in both models.•Involvement of CB1 receptors in 7NI–WIN cross-talk.•CB and NO antagonism in the modulation of hyperexcitability in two models of TLE.