Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice
Neuroscience(2015)
摘要
•IL-33 is released in the spinal cord during EAE.•Astrocytes secrete IL-33 actively upon inflammatory stimulation.•Blockage of the CNS local IL-33 exacerbates EAE development.•IL-33 is expressed both in the nuclei and cytoplasm of neurons in physiological situation.
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关键词
ANOVA,CNS,CSF,DCs,EAE,GFAP,HMGB1,ICV,IL-33,LFB,MS,NAWM,NeuN,PBS,SD,SEM,SPF,Th,TNF-α,Treg
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