OS1. gastric cancer
Kazuhiro Tanaka,Tokuzo Arao,Daisuke Tamura,Keiichi Aomatsu,Koh Furuta, Ken Matsumoto, Hideaki Kaneda, Koji Kudo,Y Fujita,Hisamichi Kimura,Kazuyoshi Yanagihara,Yoichi Yamada, I Okamoto, Ken Nakagawa,K Nishio,Akira Ooki, Kenichiro Yamashita, Katsuya Yamaguchi,Masako Asayama, Sayaka Kadowaki,H Hara,T Yamadamurano, M Arima, M Tada,Makoto Watanabe,Yoriko Yamashitakashima, S Shu,Keigo Yorozu,Toshinori Iwai, K Hashizume,Kaori Fujimotoouchi, N Harada,T Tamaki,Tomoharu Shimizu,Yuichi Katashiba,Hiroshi Mikayama,S Nomura, Nobuhiko Kobayashi,Ho Yeong Lim,Cheol Keun Park,Tzyhchyuan Hour, S J Chuang, C Y Lu,C Y Huang, W J Wu, Y S Pu, S W Wang,H H Wu,P C Wang,W Y Chou, C H Tang, K L Tan,Siew Hua Gan,R M Hassan,Abu Dzarr Abdullah,Azlan Husin, A Baba,R Ankathil,T Nagai, M A De Velasco, A Sato, N Nogami,Tetsu Shinkai,Toshiyuki Kozuki, A Ogino, Y Misumi,Yukio Hosomi, Takashi Shimokawa,Nobuyuki Hida,Naohiko Seki, C Honma,Hiroaki Okamoto, M Shibuya,Satoshi Morita,Kunihiro Watanabe, T Terashima, T Matsuzaki,Hisayoshi Fujiwara, A Nakaya,Ryuji Ogawa, Akiko Naitou,Yasuhiro Seki, Atsushi Kinoshita, M Gouchi, Z Saito, Yuzuru Yoshii, T Samejima, A Seki, Yasuhiko Kaneko, Hiroshi Takeda,Kazuyoshi Kuwano,Kensuke Sekihara,Yasuyuki Okuma,Yasushi Takagi, M Iguchi, T Okamura, R Yoshino, Y Tomizawa, Y Miura, M Nishioka,Akira Yoshii,Shin Watanabe, R Saitou,Miwako Mori, M Nagata, Tohru Kimura,Toyotaro Suzumura, Tomonori Nakai, Kenji Umekawa,Hideo Tanaka, K Matsuura,Shigeaki Mitsuoka,Nagahisa Yoshimura,Suguru N Kudoh, Kouichi Hirata, Masanori Morise, Takashi Mizutani,Toyoko Oguri, Nobuaki Imai, Taro Hase, Yasuhiro Shindo,Yoshiaki Inukai, Shokichi Ito, Nobuo Hashimoto, Miki Sato, Masaaki Kondo, Y Hasegawa, C Kondo,Jaesung Park, J Shimizu,Yoshihiko Horio, Koji Yoshida,Yasushi Yatabe,Toyoaki Hida,Shuji Bandoh,Nobuhiro Kanaji, Toshiro Matsunaga, Tsuneo Yasue,Tokuji Hirashima, Motohiro Kobayashi, Noriko Okamoto,Hiroyuki Suzuki, K Hosono, Naoki Morishita,Y Matsuura, Motohiro Tamiya,Takayuki Shiroyama, Takao Matsumoto, H Morishita, K Kawahara,Ichiro Kawase, K Isobe, Yoshiaki Hata, Naohiko Hirota, G Sano,Koichi Sato, Keishi Sugino,Shinichi Sakamoto, Yoshihiro Takai, K Shibuya, Kenji Takagi,Shunichi Homma,Toshikazu Nakamura, Naoko Aragane, K Iwanaga, K Komiya, S Hayasi,Eisaburo Sueoka, S Kimura,Ryo Toyozawa, Y Katou, Hitomi Umeguchi, S Hayashi, L K Chi, Lee Young Kwan, T K Fai, J Tong, Chen Wu, Michael Hsin, Euiheon Chung, C Wong, T M S Kam, R Takahashi,Fumio Imamura,Kiyoshi Komuta, T Kijima, Y Namba,Kunihiko Nishino, Shimpei Yamamoto, Hirokuni Hirata,Isao Tachibana,Atsushi Kumanogoh, Akira Hata,Ryuji Kaji, S Fujita, Junko Takeshita,Koichi Monden, Kazuki Nagata, Shigeki Nanjo, Kenji Otsuka, Ryo Tachikawa, M Hayashi,Kunitoshi Tomii,Naoto Katakami,Hidetoshi Kubo, K Tada, T Funakoshi, T Tsushima,Yoichi Shibata, H Tabuse, H Sawai,Satoshi Hamauchi, Hiroaki Taniguchi,Akiko Todaka,Takeshi Yokota,Noboru Machida,Koichi Yamazaki,Akira Fukutomi, H Yasui, Yuichi Onozawa,Narikazu Boku,Y H Chen, H I Lu, Kunming Rau, Y C Chiu, Y M Wang, C T Liu, S H Li, Yoshifumi Horita, Shinichi Hirai, Akiyoshi Shimatani, Kenji Matsuda,Keiichi Hiramatsu,Mitsuhiro Matsuda,Hiroyasu Ogino, Y Noda, Hironobu Miyamoto, T Kojima, Tetsu Yano,Sadamoto Zenda, Nobuo Fuse, T Yoshino, Toshihiko Doi, K Kaneko, Tetsu Akimoto, Atsushi Ohtsu,Kiyoko Kato, N Hokamura, Kazunari Akiyoshi, Yudai Honma, S Iwasa, Tsuyoshi Hamaguchi, Yukako Shimada, Hidenori Watanabe, Ikue Hoshi, Yoshikatsu Nakai,Takashi Yana, Kazunori Nosaka,Masatoshi Nakamura, Naoki Mori, K Mouri, Kouichi Ozaki, Kengo Masa, Y Horiuchi, N Moto, Kiyoshi Migita,Hirotaka Iwase, Yasutaka Tono, T Mizuno,Ken Saito, Shinji Tamaru, Y Yamashita, H Oda, Shunji Kageyama, Naohisa Katayama,Toshikazu Onikubo, K Nakamura,Hiroyoshi Matsuoka, Chihiro Makimura, Koichi Okamoto,Wataru Okamoto, Y Fujisaka,Junji Tsurutani, M Ootsuka,Kwang An Kwon,Sung Yong Oh,Hee Young Kim,Tae Min Kim, Nanette R Lee,Hyun Ju Lee, S H Hong,Sun Young Rha, Inkyu Park, Chungkun Song,Chul Sung Kim, S H Park,S H Lee, Y M Cho, J M Sun,Keun Ho Park,Soo Jeong Koh,Wan Ki Bae, J C Jo,Yeon Soo Kim,H Kitamura,Fumimasa Fukuta, Nobuhiro Nishiyama, Toshikatsu Tanaka,Naoya Masumori, T Tsukamoto, Masanori Sugimoto, Hisao Hirama, Yoshiyuki Kakehi, Jun Ya Hori, K Kitahara, K Hashidume, N Wada,Gaku Tamaki, M Kita, Toshiro Motoya, T Iwata, S Matsumoto,Hidehiro Kakizaki, N Matsubara, H Mukai, Yuji Naito, Takeshi Yamaguchi, M Sasaki, Masahiko Nezu, Kohji Itoh, R Mauchi, N Goto, Hiroshi Tsurumi, T Hara,Norio Nakamura, Hiroyuki Nakamura, Jun Nagano,Junichi Kitagawa, Noriyoshi Kanemura, Tomohide Takami,Hisataka Moriwaki, Yosuke Ishii, Noriko Tomita, S Sakata, Kazuhide Takeuchi,Ukihide Tateishi,Richard M Watanabe, R Sakai,Yoshiaki Ishigatsubo, T Yamauchi, Y Matsuda,Koji Ito, Katsuhide Fujita, M Takai, Naoya Hosono, Satoshi Ikegaya,S Kishi, Akitoshi Yoshida, Y Urasaki, H Iwasaki, T Ueda, K Tanimoto,Morishige Takeshita, Seisuke Okamura,Tsukasa Koyama, D Gomi, T Enokida, Hiromitsu Takeyama, Yoshiki Nishida, Tsutomu Mikawa, Yasuhiko Ozaki, Yoko Sugihara, D Hamaguchi,Yusuke Nakamura, M Nagano, Y Oyama, Eiichi Ichiki, K Kuramoto, Rieko Sekine, T Taniyama, Kouichi Hashimoto,Akiko Y Hirakawa,Noriyuki Katsumata,Masaki Kodaira,Kim M Yonemori,Mayu Yunokawa, Chikara Shimizu, Koichi Tamura,Masashi Ando,Yasuhiro Fujiwara, S Kawabata, T Kouno, Tadashi Mori, Asako Shimoda, M Yoshino,Shizufumi Ebihara,Akira Kido,Kanya Honoki,Motohiro Imano,Yuji Tanaka, Jun Ho Ji, Bing Han,Dae Hee Lee,Jong Seog Ahn, M J Ahn,M J Kim,Ki Won Lee,J H Kim, S M Bang,J S Lee, Yasuo Nakahara,Manabu Akahane,Yoshinari Ookuma, K Karasawa,Hiroyuki Ishida, Y Ohki, Koichi Ishida, Shinji Kusumoto, Takashi Sugiyama, T Shirai,M Nakashima, Toshifumi Yamaoka, K Okuda, T Ohnishi,Tetsuro Ohmori, Tomoya Hirose, Hiroaki Ikeda,K Kasahara,Hisayo Koba, Kenji Kurokawa, Shinji Nishikawa, Akira Sakai,Yuichi Tanbo, T Araya, Toshimasa Sone,Junya Fukuoka, M Fujimura, Shoichiro Nakao, Masaharu Yoshihara,Yasutoyo Takeyama, Naoyuki Yogo, M Ohdate, Yutaka Fukui, Hiroyuki Gonda,Ryosuke O Suzuki, Y Ueda, Tsuyoshi Takahama,Katsunaga Sakai, Hiroshi Miyawaki,Tetsushi Yoshikawa,Takahiko Misao,Motoi Aoe, Tadashi Ishii, Takahiro Yamagishi, K Shimizu,Nagio Takigawa,Masanori Nakata, Toru Kita,Chihiro Nishijima,Makoto Inaoki, Shin Yamada, Chiharu Tabata,Takashi Nakano, K Fukuoka, Akira Mogi, Y Nakashima, Eisuke Sato, Yuji Ikari,Naoko Kunami,Hiroo Katsuya, M Goto, M Ishizu, Kentaro Ishizuka, Yuzo Takamatsu, T Eguchi,Kinichiro Miura, Hiroyuki Agatsuma, T Sakaizawa, Genya Saito,Makoto Hashizume,Mitsuru Toishi, Tsuyoshi Shiina, Takashi Koizumi, Taehwan Lim,Yong Min Ahn, S H Nam,B S Kim, Hiroki Nakagawa, Kei Yamamoto, A Simoyama, Yasufumi Kubota,S Ota, S Hirano,Y Takeda, Go Naka,Motoyasu Iikura,Harushi Udagawa,Satoshi Izumi, H Sugiyama, Koji Muraki, Hirotaka Imai,Takehito Shukuya,Riyako Ohhashi, R Koyama, Hiroshi Murakami,Toru Takahashi, N Yamamoto, Kazutoshi Takahashi, T Shiraishi,Isao Takahashi, Kohki Fukuhara, Hirochika Inoue,Rinshyun Shimabukuro, Sho Maruyama, Yasushi Ikeda, Isamu Yamaguchi, Hiroshi Hashimoto, T Kanematsu,Tomoaki Fujisaki, T Nishizaki,M Fujii, Satoru Miyamoto, Yuka Igeta, Atsushi Toyoshima,Osamu Maeda, Toshio Ando, K Ishiguro, O Watanabe, T Kamiya, S Mimura, Makoto Ujihara, Y Hirayama,Kimitomo Morise,Kohei Funasaka,Ryoji Miyahara,Naoki Ohmiya,Keita Itatsu, Yasuhiko Ando, Hiroyuki Goto, M Yamauchi, K Shinozaki,Miwako Doi, Keiko Hamai,Kazuyuki Suzuki, Shinichiro Kanno, H Wakasugi, Masayoshi Itoh, Kenichi Fujii,Akira Goto, Hyejin Hong, Yoshio Fujitani, R Yamamura, Tsutomu Araki,Yukikazu Takeoka, S Kosaka, K Ohta,Haruhiko Fukuda, T Hayashi, Mitsunori Hino, Akira Sekikawa, H Fukui, T Maruo, T Tsumura, Yoichi Okabe, Y Osaki, Takeshi Wakasa, Takashi Tomita,Takeshi Oshima, Jiro Watari, Hiroto Miwa, H Nomura, Aya Hiasa, Takao Takeuchi, A Ueda, A Hosokawa, Kohei Ogawa, A Kamuro, Hiroki Yoshita, Naoyuki Nakada, T Andou, S Kajiura, Yuji Tsukioka, Tsuyoshi Kobayashi, N Horikawa, Nobuyuki Hirai, M Terada,Takamichi Murakami, S Okazaki, T Miyamoto, M Gotoh, Hiroya Takiuchi,Masaki Yoshida, T Kii, S Kuwakado, Hideo Nishitani, Keiichi Higuchi,Natsuko Naganobu, Norio Ureshino, Hiroshi Gondou,Yong Sang Hong,Se Jin Jang,Chang Sik Yu, K P Kim,S Y Kim,Sun Jin Sym,Myunghwa Jung, E K Cho,Won Sik Lee,Jung Hwan Baek,Dong Bok Shin, Y S Koo, Young Ho Park, Noriko Takahara,Hiroyuki Isayama,T Sasaki,Hideaki Ijichi, S Mizuno, K Miyabayashi, Dai Mohri, K Kawakubo,Hirofumi Kogure, Naoki Sasahira,Keisuke Hirano, K Koike, H Kawabata, N Sakiyama, Yoshifumi Okada,Kamon Sanada, Kazunori Nakase,Koichi Mandai, Akihiro Suzuki, Satoru Morikawa, Takashi Kawamura, Ayumu Morita, Masahiro Miyata, K Uno, K Yasuda, Yoshinori Sasaki, Koichi Miwa, K Araki,Hiroshi Obaishi, M Namiki, Kenichi Ishikawa, Yukio Hashiguchi, Masayuki Kitamura, T Fukuda, Hidefumi Yoshida, Taro Ichimura, Y Matsumoto,T Yasui, T Sumi,Osamu Ishiko, Yukiko Hasumi, K Kubota, Akihiko Numata,Tomoya Tsukazaki, K Horie, H Yokota, Hiroshi Takamori, T Karasuno, Toshihisa Kotake, Takashi Morikita,Sachio Hirokawa, Wataru Shioyama,Makio Mukai,Eiroh Tone, Hisashi Harada,Nobuhisa Awata,Masatsugu Hori,Yuji Arai, Kazuhiro Nishimura, T Yamazaki,Emiko Noguchi, Yasushi Omuro, M Kudo,T Shimoyama, Erika Sasaki, Ryuichi Okamoto,Yasuaki Maeda,Shinichiro Horiguchi,Tsunekazu Hishima, H Nishimori, H Nishimoto,Noriko Kouge,Youko Tsuyumu, Shouji Matsushima,Michiyo Kuyama, Masaaki Fukutake, Y Inoue, Masahiro Fujita, Kohji Hotta,Masahiro Tabata, Ichiro Miki, Hajime Nakahama, N Katusmata,Toyohide Watanabe,Hiroshi Kaneko,Yasuo Tsutsumi, Junichiro Kuroda, S Horiike, S Yokota,Masafumi Taniwaki, Makoto Sakai, Takashi Kubota,Takayuki Ikezoe,Kazuto Togitani, A Yokoyama, Toshiya Kagoo,Kadoaki Ohashi, T Hosoda, S Soma,Shuken Boku, Hiroshi Ueno, Toshihiko Yoshimasu, Shinsuke Oura,Fusao Ota, Yukihiko Hirai, K Naito, Ryosuke Nakamura, Mitsuo Ikeda, Yoshitaka Okamura,Jo Ishizawa, Eri Matsuki, D Abe, A Yamane, H Kunimoto, Y Ono, Toshiaki Kikuchi, M Sakurai, Shinichi Nakatsuka,M Inoue, J Kato,Yuzo Miyakawa, Shinji Okamoto,Ryuya Yamanaka,Akira Kawaguchi,Tatsuyuki Kakuma, Y Sakai,Yasuyuki Fujii, Kazunori Okada, Tetsuya Yoshida, Yusuke Shimizu, T Kitani,Reiji Aibara, K Morioka, Yoshiteru Tada, T Miya, S Kuzu,Yoshihiro Kokubo, Noriaki Motohashi, Akihiko Gemma,Chi Hoon Maeng, M K Choi,Joo Yeon Hong,Hee Kyung Ahn, Hyun Ae Jung,Dae Wook Hwang, Y Sunakawa,Shigehira Saji, Yuki Kato, Yuko Kanbayashi, Kimie Nomura, Haruko Daga, H Okada, Kazunari Taira, S Tokunaga, Katsuyuki Takeda, Naoki Miyamoto, Makoto Hattori, Susumu Sasada, Osamu Morimura, Kazuhiro Okafuji, K Chikamori,Keisuke Aoe,Daizo Kishino,Hideki Katayama, K Oishi, Chihiro Seki, Y Murata,Kenji Sakamoto, M Okumura, T Maeda,Hiroshi Ueoka, Yoshiyuki Ishiura,H Yamamoto,Yasukazu Terasaki,Wakaba Fukushima,Haruto Hirosawa, F Tanikawa, Hiroko Hayase, K Maruyama, C Oabata, N Hirokami,Tsutomu Masaki,M Sugiyama, S Kimbara, M Toyoda,Naoko Chayahara, Y Imanura,Naomi Kiyota, Taro Shimada,Toru Mukohara, Hitomi Minami, T Maki, Minoru Omi,Atsuya Yonemori, Kenichiro Misu, Hiroaki Inomata,Kurt T Nihei,Keiichi Hokkoku, Hiroaki Kitade, Yohei Yoshimitsu, M Okuda, K Shintaku, Takeo Shimasaki, E Fukutani,Kenji Kawada, Kenya Honda, Hiroyuki Katou, F Nomura, Hisakazu Kato, Shigeru Hatabe,Hideki Hayashi, K Okuno, Yoko Ichikawa, Takashi Shimamura, Mayumi Kijima, Itsuro Endo, M Fukuda, T Otsuka, Shinichi Kamachi, Tetsu Akiyama, M Fujimoto, S Kawazoe, Yuki Imamura, N Chyayahara, M Nishimura, Y Funakoshi,Haruaki Tomioka,Kimikazu Yakushijin, A Okamura, Hiroyuki Imaoka,Kenji Yamao, Susumu Hijioka, K Hara, N Mizuno,S Kondo,Masahiro Tajika, Taku Ogura, Takeshi Obayashi, Yasue Niwa, Shigeki Mitsunaga, Iwao Ohno, S Shimizu, H Takahashi, Hiroki Okuyama, Ayuko Kuwahara,Takuji Okusaka,Chigusa Morizane,Atsushi Ochiai, Hitoshi Kotani, Masatomo Takahashi, M Takase, K Shibata, R Kameda, Satoru Kobayashi, Masahiro Ueno, Shinji Ohkawa,K H Seong, Jungu Choi,Akio Inoue, Shinichi Inoue, Takao Maruyama, Hiroyuki Akaike,Hitoshi Fujii,Susumu Kanazawa,Hiroshi Ogata, F Saito,Toshihiro Ito,Shunko Magoshi, Koh Shingu, Gou Kaneko,T Fujisawa, T Hirakata, Yasuhiro Yanagita, M Yamane, Kunihiro Myo, Takeshi Morimoto, Takao Nomura, Yoshihito Shiota, Y Okamoto,Toshinobu Shimoi, E Sasak, K Yakushijinn,T Ogawa, Masao Yonemura, K Kawasumi, Y Aoyagi,Satoshi Ueno,Yukinobu Ichida,Yuichiro Ohe, Kotaro Endo,Kouji Izumi, S Ogawa, K Takashima, K Masuo,Masanori Fukushima, M Wada,Naoto Shimeno,Hajime Tei,Yoshiki Suginoshita, A Okada,Takamitsu Inokuma,C C Liao, T L Chen, C C Shih, N Takeuchi, Norifumi Kubo, Atsushi Nakayama, Tadashi Terui, Toru Kusakabe, T Ishihara, Kunihiko Ishitani, Shigeru Iyama,Toshio Sato,Rogerio Yugo Takimoto,Masafumi Kobune, M Manabe, Teppei Nishii, Hiromi Nakano, T Takakuwa,Yasuhiro Aoyama, T Kumura,Atsuko Mugitani, Hitoshi Tsuchihashi,Wataru Yamamoto,Hirotaka Takasaki, Shinji Motomura, Masamitsu Iino, Hiroshi Nakagomi, Ken Teramoto,Atsushi Okamoto, A Abe, M Okamoto, Yoshiyuki Inaguma, Masato Kanie,Yuji Yamamoto, Marcos De Sales Guerra Tsuzuki,Yoshiki Akatsuka, Satoshi Mizuta, Nobuhiko Emi, Yuji Kikukawa,Yutaka Watanabe, T Shimomura,Hitoshi Suzushima, H Ichihara,Hirohisa Nakamae, A Hirose, Tomoo Nakane,Hyongjong Koh,Y Hayashi, Makoto Nisimoto, M Nakamae, Yasushi Terada, Takuya Yoshimura,Mizuki Aimoto,K Hagiwara, Kiyofumi Yamada,Osamu Kondo, Akira Sawada, Masahide Yasui,Yumie Takeshita, Akiko Ioka,Keisei Kawa
ANNALS OF ONCOLOGY（2012）
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摘要
ABSTRACT SRPX2 (Sushi repeat-containing protein, X-linked 2) has recently emerged as a multifunctional protein that is involved in seizure disorders, angiogenesis and cellular adhesion. Here, we analyzed this protein biochemically. SRPX2 protein was secreted with a highly post-translational modification. Chondroitinase ABC treatment completely decreased the molecular mass of purified SRPX2 protein to its predicted size, whereas heparitinase, keratanase and hyaluroinidase did not. Secreted SRPX2 protein was also detected using an anti-chondroitin sulfate antibody. These results indicate that SRPX2 is a novel chondroitin sulfate proteoglycan (CSPG). Furthermore, a binding assay revealed that hepatocyte growth factor dose-dependently binds to SRPX2 protein, and a ligand–glycosaminoglycans interaction was speculated to be likely in proteoglycans. Regarding its molecular architecture, SRPX2 has sushi repeat modules similar to four other CSPGs/lecticans; however, the molecular architecture of SRPX2 seems to be quite different from that of the lecticans. Taken together, we found that SRPX2 is a novel CSPG that is overexpressed in gastrointestinal cancer cells. Our findings provide key glycobiological insight into SRPX2 in cancer cells and demonstrate that SRPX2 is a new member of the cancer-related proteoglycan family.
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关键词
NET G2,well-differentiated neuroendocrine carcinoma,dacarbazine,primary hepatocellular carcinoma,three-dimensional conformal radiation therapy,volumetric modulated arc therapy
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