A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia

Timothy P Hughes,L Hansson,Ida E Sonderby,Lavinia Athanasiu,Verena Zuber,Martin Tesli,Jie Song,Christina M Hultman,Sarah E Bergen,Mikael Landen,Ingrid Melle,Ole A Andreassen,Srdjan Djurovic

Biological Psychiatry（2016）

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摘要

Our results suggest that an elevated expression of this transcript starting in adolescence may be an important factor in the pathophysiology of schizophrenia and bipolar disorder.

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关键词

ANK3,Bipolar disorder,Genetics,Minor isoform,Schizophrenia,Splice site

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