Epitope-specific antitumor immunity in differentiated thyroid cancer causes thyroglobulin antibody production in DTC patients

Aims: The occurrence of anti-thyroglobulin-antibodies (Tg-Ab) is a frequent problem in the follow-up of patients with differentiated thyroid cancer (DTC). The reason for the occurrence of these Ab's is yet unknown. Recently it has been reported that these patients and that showing lymphocytic tumor infiltrates have a better outcome compared to those without. The aim of this ongoing study is therefore, to investigate epitope-specific antitumor immunity in DTC patients.