Abnormal resting-state regional homogeneity in unmedicated bipolar II disorder.

•Regional intrinsic neural activity changes in unmedicated bipolar II disorder by ReHo method.•ReHo decreased in the orbitofrontal cortex, and increased in the precentral gyrus, supplementary motor area and middle occipital gyrus.•Disrupted balance between the prefrontal cortex and primary sensorimotor regions may particularly contribute to the pathophysiology of BD.