Genome-derived cytosolic DNA contributes to type I interferon expression and immunogenicity of B-cell lymphoma cells

Yu J. Shen,Samantha S.W. Ho,Nikki Y. Tan,Christine Xing’Er Koo,Muznah Khatoo,Florence S.G. Cheung,Stephan Gasser

Cytokine（2015）

引用 2|浏览9

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摘要

•Genome-derived ssDNA, dsDNA and DNA:RNA hybrids are present in the cytosol of tumor cells.•Cytosolic DNA can potentially form non-B DNA structures.•Cytosolic DNA contributes to type I interferon-dependent immune rejection of B-cell lymphoma.

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关键词

Type I interferon,Cancer,Innate immunity,Non-B DNA motifs,DNA sensors

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