Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii -induced cytokines in vitro

Anne Ammerdorffer,Mark H T Stappers,Marije Oosting,Teske Schoffelen,Julia C J P Hagenaars,C P Bleekerrovers,Marjolijn C Wegdamblans,Peter C Wever,Hendrikjan Roest,Esther Van De Vosse,Mihai G Netea,T Sprong,Leo A B Joosten

Cytokine（2016）

引用 7|浏览37

暂无评分

摘要

•The role TLR10 in cytokine production and development of chronic Q fever is examined.•The reference strain Nine Mile and the Dutch outbreak isolate 3262 are compared.•TLR10 inhibits cytokine production by C. burnetii stimulated PBMCs.•SNPs in TLR10 influence cytokine production by C. burnetii 3262 stimulated PBMCs.•Genetic variation in TLR10 does not lead to increased risk to develop chronic Q fever.

查看译文

关键词

Q fever,Coxiella burnetii,Toll-like receptor 10,Single nucleotide polymorphism,Innate immunity

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要