Investigation of the pharmacokinetics of a novel sustained release metformin hydrochloride suspension with ion exchange resin as carriers in beagle dogs

A novel metformin hydrochloride sustained-release suspension containing ion exchange resin as carriers have been reported in a previous study. In the present study, the pharmacokinetics of this sustained-release suspension in beagle dogs was investigated. A high performance liquid chromatography (HPLC) method was established to detect the amount of metformin hydrochloride in vivo. The pharmacokinetics parameters of the metformin hydrochloride sustained-release suspension and a reference metformin hydrochloride tablet were: AUC(0-24) (mu g . h . ml(-1)) 72.94 and 78.07, C-max (mu g . ml(-1)) 7.97 and 15.42, T-max (h) 4.2 and 1.83 respectively. The results indicated that the suspension was bioequivalent with the reference tablet, and had an obvious sustained-release effect.