Novel structural features increase the antioxidant effect of estrogen analogues on low density lipoprotein

Alan F. Fidarov,Veera Vihma, Roman P. Bogautdinov, Svetlana N. Morozkina, Alexander G. Shavva,Matti J. Tikkanen

The Journal of Steroid Biochemistry and Molecular Biology（2015）

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摘要

•A six-carbon d-ring increased the antioxidant activity of estrogen analogues.•Estrogen analogues with a fluorine atom at C-2 were potent antioxidants.•Unsaturated analogues with a substituted 3-OH group inhibited lipid peroxidation.

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17β-E2,LDL,Log P,SD

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