Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics

Sergio Anastasi,Dante Lamberti,Stefano Alema,Oreste Segatto

Seminars in Cell & Developmental Biology（2016）

引用 22|浏览18

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摘要

•MIG6 plays a necessary role of in negative feedback regulation of ErbB receptors.•MIG6 suppresses EGFR signaling via kinase inhibition and down-regulation.•MIG6 loss enhances oncogenic ErbB signaling.•MIG6 loss in tumors is a potential biomarker of oncogenic addiction to ErbB signaling.

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关键词

RTK,EGF,EGFR,LRIG1,MIG,RALT,ERRFI1,SOCS,EBR,TKD,ARF,RED,CBL,HGF,PDGF,FGF,GPCR,JNK,MAPK,ERK,FOS,AP-1,LPA,FOXO,EMT,UTR,HSP,TKI,NSCLC,IHC,GBM,TGFβ,PTEN,SMAD,CRC,DMBA,DNMT,PTC

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