0087: Progressive increase in ventriculo-arterial impedance is associated with LV disfunction and adverse outcomes in patients with severe aortic stenosis

Introduction ventriculo-arterial impedance (ZVa) is recognised as influencing exercise tolerance, sincope onset and prognosis in aortic stenosis (AS) patients Aim of the present study is to show that increase in ZVa is associated with impairment of left ventricular (LV) function and adverse outcome in AS. Methods 218 patients (mean age: 79.9±8.6 years, males: 54%) with severe AS (aortic surface Results according to ZVa values our population was divided in four groups (Table 1). Progressive increase in ZVa was associated with a progressive reduction in LV ejection fraction (LVEF), mitral S’, indexed stroke volume (SVi) and LV global longitudinal strain (GLS). At Kaplan-Meyer survival analysis, a ZVa >3.43 mmHg/ ml/m2, as observed in Group B, C and D patients, was associated with a poor prognosis (Log-Rank test, p=0.02) Conclusions in patients with severe AS, progressive increase in ventriculo-arterial impedance has a negative impact on LV performance, and a mild elevation in ventriculo-arterial impedance is associated with a poor prognosis. Abstract 0087 – Table1 Table 1 Group A ZVa ≤ 3.43 mmHg/ml/m2 Group B 3.43 Group C 4.1 Group D ZVa>5.10 mmHg/ml/m2 ANOVA p-value LVEF (%) 57.9±10.8 58.6±9.5 56.8±12.9 50.64±14.5 0.02 SVi (ml/m2) 49.6±14.0 47.3±7.1 40.9±5.9 31.6±6.8 Onde S’ (cm/sec) 6.2±1.2 6.5±1.6 6.21±1.9 5.6±1.5 0.05 GLS (%) - 14.4±13.3 - 13.3±3.4 - 12.5±3.5 - 10.6±3.2