Correlating chemical sensitivity and basal gene expression reveals mechanism of action

NATURE CHEMICAL BIOLOGY（2015）

引用 471|浏览44

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摘要

computational tool provides a systematic approach to determine the mechanisms of action of small molecules by examining correlations between basal gene expression and small-molecule sensitivity in cancer cell lines.

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关键词

Cancer therapy,Mechanism of action,Small molecules,Target identification,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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